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Porter Nitronox Plus Nitrous Oxide & Oxygen Analgesia Systems

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The Nitronox Plus Nitrous Oxide and Oxygen System by Porter Instrument is a safe, easy-to-use regulator that delivers a controlled mix of oxygen and nitrous oxide—commonly known as laughing gas. It provides fast-acting, short-term relief from pain and anxiety during medical aesthetic and medical procedures. With over 50 years of proven reliability, Nitronox helps keep patients comfortable during RF microneedling, laser treatments, and other procedures known for higher discomfort—such as fractional CO₂ resurfacing, Ultherapy, tattoo removal, lip fillers, and more. 

The Only Fully Adjustable Nitrous Oxide System on the Market 0-70%:
Competitive systems are limited to a fixed 50/50 nitrous oxide and oxygen mix, which doesn’t work for every patient. Nitronox Plus offers an adjustable 0-70% model that gives you full control, allowing you to customize the nitrous oxide level based on patient sensitivity and comfort needs. Start low and adjust up for those who require more relief—all while ensuring a smooth, predictable experience. At the end of the procedure, a 100% oxygen flush clears the system, something fixed-ratio systems can’t do.
Considering adding nitrous oxide to your practice? Contact Us 

Benefits to Your Practice:
  • Complete procedures more efficiently
  • Reduced recovery time and liability for patient monitoring
  • Decrease "treatment dropout"
  • Increase revenue by charging for nitrous oxide
Choose from three models tailored to your needs:
  • 0-70% adjustable nitrous oxide (NOX-PLUS-070-2NS)
  • 0-50% adjustable (NOX-PLUS-050-2NS)
  • 50/50% fixed system (NOX-PLUS-5050-2NS)
Which model will work best for your practice? Feel free to chat, call us at (800) 880-8260, or click the Request More information button below...

Demand flow system with enhanced safety features:

• Available in fixed or adjustable mixture concentration models
• Key lock mechanism for safety and security
• Audible low gas pressure alarm
• Internal but accessible demand valve that never requires recalibration
• Safety function test button

Designed to meet infection prevention standards:

• One-way directional flow of inhaled and exhaled gas
• Single-use, disposable breathing circuits
• Single-use masks and mouthpieces
• Front panel user interfaces designed to prevent surface cleaners and disinfectants from entering the device

Each unit comes with a 2-cylinder cart

Regulator Dimensions: 11” x 11” x 8” (28cm x 28cm x 20.3cm)
Weight: 13 lbs (5.9 kg)

Tank Type:
• Uses standard “E” cylinder or "E" Type Tank
• Available from medical gas suppliers
• At normal breathing rates, gas supply will last approximately:
• N₂O: 6 hours
• O₂: 2 hours

Gas Supply Pressure:
• O₂: 45 to 60 psi (310.3 to 413.6 kPa)
• N₂O: 45 to 60 psi (310.3 to 413.6 kPa)

Alarm Activation:
• Whistle alarm signals a low gas supply when the pressure drops to approximately 35 psi (2.41 bar)

3-Year manufacturer warranty

Porter Instrument is the foremost authority in nitrous oxide equipment and is renowned for its Nitronox Plus system. As the leader in nitrous oxide sedation systems for the Med Spa/aesthetic medicine and medical wellness markets, Porter Instrument has been manufacturing the highest-quality medical equipment since its establishment in 1968. A commitment to precision and safety, and a legacy of innovation and quality make Nitronox Plus the go-to choice for medical nitrous oxide analgesia systems.

Demand flow system with enhanced safety features:

• Available in fixed or adjustable mixture concentration models
• Key lock mechanism for safety and security
• Audible low gas pressure alarm
• Internal but accessible demand valve that never requires recalibration
• Safety function test button

Designed to meet infection prevention standards:

• One-way directional flow of inhaled and exhaled gas
• Single-use, disposable breathing circuits
• Single-use masks and mouthpieces
• Front panel user interfaces designed to prevent surface cleaners and disinfectants from entering the device

Each unit comes with a 2-cylinder cart

Regulator Dimensions: 11” x 11” x 8” (28cm x 28cm x 20.3cm)
Weight: 13 lbs (5.9 kg)

Tank Type:
• Uses standard “E” cylinder or "E" Type Tank
• Available from medical gas suppliers
• At normal breathing rates, gas supply will last approximately:
• N₂O: 6 hours
• O₂: 2 hours

Gas Supply Pressure:
• O₂: 45 to 60 psi (310.3 to 413.6 kPa)
• N₂O: 45 to 60 psi (310.3 to 413.6 kPa)

Alarm Activation:
• Whistle alarm signals a low gas supply when the pressure drops to approximately 35 psi (2.41 bar)

3-Year manufacturer warranty

Porter Instrument is the foremost authority in nitrous oxide equipment and is renowned for its Nitronox Plus system. As the leader in nitrous oxide sedation systems for the Med Spa/aesthetic medicine and medical wellness markets, Porter Instrument has been manufacturing the highest-quality medical equipment since its establishment in 1968. A commitment to precision and safety, and a legacy of innovation and quality make Nitronox Plus the go-to choice for medical nitrous oxide analgesia systems.

FAQs

Is the Nitronox® Plus nitrous oxide and oxygen system safe?

How fast does nitrous oxide take effect and last?

How much can my practice charge for Nitrious Oxide?

Does nitrous oxide eliminate pain?


Questions & Answers

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  • Can an RN administer nitrous oxide in our practice?

    In most cases, medical clinicians like RN's can administer nitrous oxide and oxygen using a system like Nitronox Plus, as long as it falls within their professional scope of practice. While there may not be a specific regulation that names nitrous oxide directly, its use is generally considered part of minimal sedation, analgesia, or anxiolysis—similar to administering a local anesthetic. The key is that the treating clinician must ensure it aligns with their state’s practice guidelines and that proper training, protocols, and medical oversight are in place. If your license allows you to administer medications for mild sedation or pain relief, you are likely eligible to use Nitronox Plus in your practice. Always check with your state regulatory boards to confirm it is permitted within your scope of practice.

  • How do you prevent Diffusion hypoxia when on demand is used and therefore the patient is not receiving 100% oxygen administration after nitrous oxide cessation?

    This is one huge benefit of Nitronox Plus. It can deliver 100% oxygen by either turning the knob to 0% nitrous or turning the key to the off position. For that reason, we fully recommend doing that at the end of every procedure.